Results that tell you
something.
Your tests haven't fully explained your condition, but you know something is happening in your biology.
We believe you.
Help build one of the most comprehensive datasets in medicine and get individualized research reports back. Contribute your health records, biospecimens, and lived experience and join the mission to find effective treatments for complex chronic conditions. You’ll find out what our scientists are uncovering about your biology as the study unfolds.
What we measure
Data points generated across
multiple layers of biology
Most research studies only test one layer. We look at several at once. With up to five omics assays, our AI tools can provide deeper analysis.
3.2 billion base pairs28 million+ CpG sites20,000 genes2,000 metabolites1,000 proteinsMobile Sample Collection
Adults 18+ in the US can join the Chronicle Biobank Study from home. The cost for mobile sample collection is $400. Research studies are often run in batches, meaning we send off groups of samples at once for testing. Sign up below to be notified when an enrollment window opens to become part of our next cohort.
Sign UpCreate an account in Chronicle Connect and choose the at-home option.
One Draw. Five Omics.
About the Reports
We let the data dictate the discovery, so analyses will shift over time. Your research reports will show you which assays scientists ran on your sample and what the results mean about your biology in the context of the study. Your research reports may reveal information about how your energy pathways and immune system are functioning, genetic factors that could influence your health, and how your body tends to respond to stress and illness.
We measure 2,000 metabolites. Those are the small molecules your body makes when it digests food, makes energy, fights infection, or repairs cells.
Proteins carry out almost every biological function in your body. We measure how your protein expression compares across key biological pathways providing a functional picture of what's happening right now.
Gene expression shows which biological processes are most active in your body.
Your genomic data provides insight into your DNA and the molecular switches that turn genes on or off, and how things like illness and inflammation influence them.
Methylation changes gene expression by adding chemical tags to your DNA. But these tags aren't static. They can change. Infection, stress, inflammation, aging and other events can all shift methylation patterns.
Research Use Only
These results are for research use only and are not diagnostic. Findings describe real-time observations and can change as the science evolves. They can't be used to diagnose, monitor, or guide treatment.
How it works
Research Where You Are
Sign up for at-home sample collection or join the biobank at no cost at one of our partner clinics.
Visit our research platform and choose the collection option that works for you. Complete the sign up process.
For on-site appointments, please reach out to the clinic directly to schedule. For a current list of clinic partners, please see our FAQs below. For mobile visits, we’ll reach out when the next enrollment window opens.
We'll run multi-omic analysis. Our scientists also review the health records and surveys you share, adding your lived experience to research understanding.
Your individual research report will appear in your portal in 9–12 weeks. They’ll show which assays our scientists ran and what they uncovered.
About the Study
Uncover Patterns Others Miss
This is a longitudinal study that collects high-quality data at multiple time points. We invite you to contribute up to three times over six months. You'll receive new reports after every collection that will reflect what our scientists are finding as the research unfolds.
What participation includes
Standard Blood Draw
We collect four tubes of blood using a butterfly needle. Some clinics also request a urine sample and cheek swab.
Sync Health Records
Connect at least one medical record in our platform. This helps us understand health information that can't be captured through a sample alone.
Complete Surveys
Take brief symptom and lifestyle surveys ahead of each collection. Your lived experience adds vital context to what your biology reveals.
Research Reports
Once analysis is complete, you'll receive your report in Chronicle Connect. It'll have data for you and insight into the research it's informing.
Every finding matters
Thank you for being part of the next chapter of discovery.
Every sample adds to a reference these conditions have never had. The larger our dataset grows, the more clearly patterns emerge, and the closer we get to therapeutic targets.
Most research participants never see results, or wait years for a publication. We know any information to help understand your body can be useful when you're navigating a chronic illness. That's why we share reports with our participants along the way. If findings point toward targets that match your biology, you'll be among the first to know.
We make a chronically awesome team.
FAQs
Ask away. We love finding answers.
A biobank is an organized collection of biological samples like blood, tissue, and DNA, stored alongside health information and studied over time.
No. This is a research study, not a clinical test. Research reports show where your biology sits in relation to the research cohort, but it is not a diagnosis and should not guide medical decisions. The assays used are research-use-only (RUO) and have not been cleared by the FDA for diagnostic use. Always consult a qualified healthcare provider with any medical questions.
Research-use-only (RUO) means the assays we use have not been validated under CLIA and have not been cleared or approved by the FDA for clinical diagnostic use. Research reports describe research observations, not clinical findings.
You pick a time and place that works for you and a certified phlebotomist comes to your home to perform a blood draw. They usually collect four tubes and use a butterfly needle. We coordinate scheduling through GetLabs. They'll mail your samples back to us. We analyze them and return personalized research reports to you as the study unfolds. There is a cost associated with mobile sample collection. See below.
After the first cohort, the cost to participate in mobile phlebotomy is $400 per collection. A complete multi-omic workup is several thousand dollars to run each time, but we are only charging participants for the cost associated with mobile sample collection (phlebotomist, shipping, logistics). We absorb the rest since analysis is what helps us build the dataset that we hope will lead to a better understanding of these conditions. We hope to continue to find more ways to make participation affordable.
We're a small team with a big mission. We're managing capacity carefully and running our study in batches to preserve sample quality and ensure every participant has a meaningful research experience. We'll invite people to enroll in mobile sample collection in the order in which they signed up and will keep opening enrollment windows as budget and bandwidth allow. Signing up does not obligate you to enroll when your spot opens.
Our study is performed with IRB oversight and your personal information is handled in our HIPAA compliant platform. Data used in group-level analyses is de-identified. No other participant will see your individual results.
This study is open to adults 18+ in the U.S. living with, or suspected of living with, complex chronic and neuroimmune conditions, including ME/CFS, Long Covid, POTS, fibromyalgia, MCAS, Ehlers-Danlos Syndrome, Sjögren's, Persistent Lyme, and related conditions.
These results are generated through a research study and not meant to diagnose or treat disease. The assays are research-use-only and are not CLIA-validated.
Yes. Your participation is completely voluntary, and you can choose to opt out at any time. Contact our research team at research@chroniclebio.com.
If you are a patient at a ChronicleBio partner clinic, you can donate a sample in-person at no cost. Blood, urine, or cheek swab collection takes just a few minutes during your standard appointment. In-clinic participants are part of a separate cohort than those in the mobile study. Reports may be returned at a different cadence. If you live near one of our sites and would like to schedule a biobank collection, please contact the clinic directly and request a research visit. Participating clinics include: Dallas, TX The Heartbeat Clinic 214-504-9942 Flagstaff, AZ Four Peaks Healthcare 928-773-9714