Decoding the hardest disease biology to treat millions

We generate novel human disease data and train AI models to read it. Resolve one patient into the biology driving their disease and you find mechanisms shared by millions.

the problem

Chronic disease has never been defined by its biology

Chronic conditions like dysautonomia, POTS, long COVID, and ME/CFS are named for their symptoms, not the biology driving them. Two people with different diagnoses may share one. Those same two people may have different mechanisms or drivers of disease. No one has untangled these relationships, because the human data to understand them hasn't existed.

OUR APPROACH

We built the missing data layer

Our growing global network of patients and clinicians is the first of its kind in chronic disease. We started with the conditions medicine understands least, because solving them builds a way to read human biology anywhere.

OUR TECHNOLOGY

A loop that begins and ends with people

Generate

Read

Resolve

Return

Patients in our network continuously generate longitudinal, multi-omic data across the full molecular stack.

Our models read pathogenic signals from the data, including signals no one has had the resolution to see before.

Our platform resolves each patient into a biological fingerprint and ranks the druggable mechanisms driving their disease.

We validate the biology in people and return it to them, first as answers, then as treatments. Every result sharpens our models for the patient who comes next.

PROGRAMS & PARTNERS

From mechanisms to medicines

We develop therapeutics for the druggable mechanisms our platform identifies. We also partner with leading biopharma companies to put our data and biology to work for their pipelines.

about

The Chronicle team

Chronicle brings together leaders in AI, data infrastructure, and drug development who are also patients and caregivers.

Rohit Gupta

Rohit Gupta

Co-Founder & CEO

Fidji Simo

Fidji Simo

Co-Founder & Director

Rishi Reddy

Rishi Reddy

Co-Founder & Executive Chair

John Mumm, PhD

John Mumm, PhD

Chief Scientific Officer

Yambazi Banda, PhD

Yambazi Banda, PhD

Head of Platform

Summer Dashe

Summer Dashe

Head of Marketing and Communications

Genelle Harrison, PhD

Genelle Harrison, PhD

Senior Principal Translational Bioinformatician

Nagendra Athreya, PhD

Nagendra Athreya, PhD

Senior ML Engineer

Jennifer Bone, PhD

Jennifer Bone, PhD

Senior ML Scientist

Rhondene Wint, PhD

Rhondene Wint, PhD

Senior Scientist, Bioinformatics

Cortney Gensemer, PhD

Cortney Gensemer, PhD

Principal Translational Scientist & Program Director

Gnaumie-Monique Valle

Gnaumie-Monique Valle

Senior Biobank & Lab Manager

Christine Pavel

Christine Pavel

Participant Engagement Lead and Executive Assistant

Alyse Dowell

Alyse Dowell

Clinical Research Coordinator

Emily Soohoo

Emily Soohoo

Lab Technician

Sanjana Santhosh

Sanjana Santhosh

Clinical Research Coordinator

Hadia Lemar

Hadia Lemar

Lab Director

News

Forbes

,

October 1, 2026

This Former OpenAI Exec Is Trying To Cure Chronic Diseases, Including Her Own

Fortune

,

August 3, 2026

Exclusive: Former OpenAI exec Fidji Simo discusses her battle with POTS and her startup’s plans to cure it with AI and 3,500 vials of blood (so far)

Press

ChronicleBio

,

June 11, 2026

ChronicleBio is Coming for Chronic Disease: Pioneering Immunologist Joins Elite Scientific Team to Translate Biological Signal Into Targeted Therapeutics

ChronicleBio

,

August 5, 2025

Merging deep tech and biomedical science expertise, ChronicleBio aims to accelerate breakthroughs for millions living with complex chronic conditions

ChronicleBio

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June 27, 2025

Solve M.E., BIC, ChronicleBio, Complex Disorders Alliance & CareEvolution launch groundbreaking research partnership